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    Why Shouldn’t You Mix CBD And Kratom?

    CBD and Kratom are poles apart, but the issues they cater to are somewhat similar. Like Coffee and Matcha tea powder tend to boost our energy, both go through different physiological processes to bring about the effects.

    Have you heard about the notorious cannabis plant? The hemp plant (one of the species of the cannabis plant) contains enough CBD – Cannabidiol compound. You would be surprised to know that 33% of the US population has used CBD-based products for recreational purposes, and that’s pretty huge!

    CBD is exclusively available online in the form of tinctures, oils, edibles, and capsules.

    Kratom is native to SouthEast Asia. It grows on a massive tree known as Mitragyna Speciosa. Do you know what makes Kratom a unique herb? For sure, it’s alkaloids Mitragynine and 7-Hydroxy-Mitragynine. Both alkaloids are known for the health benefits they provide, and for that reason, Kratom is immensely celebrated as a botanical remedy in numerous states.  You may not know that almost 5 million people in the USA use M.Speciosa for its medical benefits.

    Both CBD and Kratom have helped millions out there in ways they would have never imagined. No exaggeration here folks, head over to Reddit and have a glimpse at the threads yourself! The user experiences are so motivational, and one realizes that the botanicals are an “unseen” solution to a wide variety of issues.

    Let’s get into further details!

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    Now that you know what CBD and Kratom are, you must be curious to learn more about them. If that’s the case, the most exciting part of this piece awaits you.

    Can you mix CBD oil and Kratom? What would be the effects? And why should you not blend CBD and Kratom?

    Let’s find out!

    What Happens When You Mix CBD And Kratom?

    Although both CBD and Mitragyna Speciosa exist naturally in nature, it does not mean you should mix them and gulp them down in your system all willy-nilly. Folks, the coast is not clear, and you need to be careful.

    How is the mixture of CBD and Kratom hazardous for your body?

    From inferring with the first-pass effect to interacting with medications, CBD and Kratom combination produce harmful consequences.

    1) CBD and Kratom hinder the effect of medications

    Do you know what happens when you take medication? They enter your small intestines and the enzyme known as Cytochrome P450 breaks down the medicine. Later, the drug enters the liver, now what happens next?

    CYP450 enzymes in the liver again metabolize the medication, and here the complete breakdown takes place. Remember, only a portion of medicine enters the liver and later into the blood. The activity is known as the first-pass effect.

    The whole reason behind explaining all the details here is to understand that CBD and Kratom combination tend to affect the first-pass effect. It binds with the active site of CYP450, hindering the binding of medicine at this site, thereby restricting the chemical influence to begin. People tend to increase their dosages so that the dose enters the liver, and later bloodstream. It is too dangerous!

    In conclusion, CBD and Kratom influence the liver enzymes, and hence they cannot break down the medicine. Do not combine both herbs, and be at the safer end.

    2) CBD and Kratom inhibit the activity of essential enzymes

    Studies show that CBD and Kratom tend to produce lasting inhibition effects on CYP450 enzymes, and your body takes at least 2-3 days to create an entirely new batch of these enzymes. To bring your drug metabolism back to its original state, you would have to wait, and during this time, the medications may not produce the effects. Individuals with an underlying condition should consider it a red flag and do not use CBD and Kratom.

    3) CBD and Kratom combination results in mind alteration

    The combination of fullspectrum CBD and Red strains of Kratom is dreadful for your well-being. It causes mind alteration, and you become unaware of your surroundings, even your existence. Hence, it is not wise to mix CBD and Kratom. It is best to take both herbs individually.

    If you are still looking for mixing Kratom and CBD safely, your health care professional may help out in this regard. Consult your doctor, and discuss everything in detail.

    CBD Vs. Kratom: Similarities and Differences

    Let’s find out how these two treasures of Mother Nature are somewhat different and similar.

    CBD and Kratom have different chemical compounds

    The research suggests that cannabis plants contain approximately 426 chemical compounds. Almost more than 60 are cannabinoid compounds, CBD is one of the essential cannabinoids existing in cannabis. 

    On the other hand, the study claims that Kratom consists of at least 40 alkaloids. The most potent ones are Mitragynine and 7-Hydroxy-Mitragynine.

    Both CBD and Kratom interact differently with our system

    According to a 2011 study, CBD influences the CB1 and CB2 receptors of our endocannabinoid system. These receptors are responsible for looking after memory, appetite, pain, movement and coordination, and inflammation.

    On the other hand, CBD also influences the 5ht serotonin receptor and TRPV1 receptor. These receptors deal with psychotic disorders, pain relief, and inflammation.

    In contrast, Kratom directly binds with mu-opioid, adrenergic, and serotonin receptors. These receptors further promote pain relief, energy boost, relaxation, and a cheerful mood.

    Although CBD and Kratom interact differently with our bodies, both exhibit numerous similar effects. 

    Kratom develop tolerance, while CBD not

    Most of the Kratom users develop tolerance against the botanical due to frequent use of higher dosages without taking tolerance breaks. The tolerance results in addiction, and one has to take enough Kratom to keep up with the body requirements. In short, Kratom is psychoactive!

    On the other hand, CBD is not addictive. It influences our endocannabinoid system and does not cause mind-alteration. That is a plus with CBD! 

    CBD is sedative in lower doses, while Kratom induces sedation at higher dosages

    Both Kratom and CBD promote relaxation and sedation, but there is a crucial difference out there. If you are looking for sedation induced by CBD, you won’t have to wait longer than five minutes. On the other hand, Kratom produces sedative effects at higher dosages, with a waiting period of 30-40 minutes.

    CBD follows extraction procedures, while Kratom is a simple dry leaf powder

    CBD is one of the essential cannabinoids present in the cannabis plant. Hence manufacturers follow two complicated extraction techniques – CO2 extraction and Solvent extraction. Later it is distilled to form potent and concentrated CBD products.

    On the other hand, Kratom is a whole leaf. Farmers hand-pick the mature leaves and dry them under controlled settings. After the leaves are entirely dry, they turn them into a smooth and granule-free powder with fast-acting grinders.

    Now you know the key differences between both substances. Let’s head over to the similarities they share. 

    Legality issues with CBD and Kratom

    The both substances fall under the legality issues. Any marijuana-based CBD product is illegal to use in Kansas, Indiana, North Carolina, South Carolina, Texas, Tennessee, South Dakota, Kentucky, and Mississippi.

    Although Kratom is federally legal to use in the USA, states like Alabama, Arkansas, San Diego (California), Sarasota (Florida), Jerseyville City (Illinois), Franklin City (New Hampshire), Rhode Island, Vermont, and Wisconsin. 

    CBD and Kratom have numerous strains

    The cannabis plant has both naturally occurring and hybrid strains. CBD coming from each strain has different names and concentrations. For example, CBD derived from hemp is known as hemp-derived CBD.

    Similar is the case with Kratom. It exists in three different strains: Red, Green, and White. Although Kratom also comes in Gold, and yellow strains, these strains are primarily derived from the three primary strains, and follow different yet unique drying procedures.

    Both have similar side effects

    Can you name something entirely free from side effects? Remember, too much of anything is bad for your well-being. The rule works on CBD and Kratom as well. CBD and Kratom may produce side effects if you do not look after your dosages carefully. The side effects include:

    • Dizziness
    • Stomach upset
    • Dry mouth
    • Loss of appetite

    Final Thoughts

    CBD and Kratom are natural alternatives for pain relief, inflammation, stress, anxiety, and the list goes on. Individuals look forward to ways they can take both herbs together, but it is entirely not recommended. The combination of CBD and Kratom affects the essential liver enzymes, thereby hindering the breakdown of medications. Moreover, CBD and Kratom mixture affect CYP450 enzymes’ production, and the new enzymes form in 2-3 days.

    Additionally, CBD and Kratom may cause mind alteration, entirely detaching you from your surroundings. Hence, one should never mix CBD and Kratom without taking advice from a professional health care practitioner.

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